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Hematological malignancies can be divided into leukemias, lymphomas, and multiple myeloma.

Lymphomas can be divided into Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.

Non-Hodgkin’s lymphoma can be subdivided into aggressive lymphoma and indolent lymphoma.

Aggressive non-Hodgkin’s lymphoma includes:
*Diffuse large B-cell lymphoma​ (DLBCL)
*Burkitt’s lymphoma.
*Mantle cell lymphoma.
*Precursor T-cell lymphoblastic lymphoma.
*B-lymphoblastic lymphoma.

Indolent non-Hodgkin’s lymphomas include:
*Follicular lymphoma
*Marginal zone B-cell lymphoma (MALToma)
*Hairy cell leukemia/ lymphoma.
*Waldenstrom macroglobulinemia.
*Mycosis fungoides/ Sezary syndrome.

Marginal Zone B-cell lymphoma is an indolent (low grade) Non-Hodgkin’s Lymphoma…It can be nodal, extranodal, or splenic. The extranodal is also known as Mucosa-associated lymphatic tissue lymphoma (MALToma). It can have B (constitutional) symptoms such as unintentional weight loss, night sweats, and fever.
Marginal zone B-cell lymphoma can transform into diffuse large B-cell lymphoma (aggressive NHL).

MALT lymphoma can have (11;18) translocation

For diagnosis, you need a core needle biopsy or an excisional biopsy of the lymph node, stomach, salivary gland, ….etc.

Treat with the “watch and wait” approach, radiation or chemotherapy depending on the stage.

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Disclaimer 1: The medical information contained herein is intended for educational purposes only, and are not intended for diagnosis of any illness. If you think you may be suffering from any medical condition, you should consult your physician or seek immediate medical attention.
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